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B., Biojone, C., da Silva, N
Gut side effects are the main event: gastrointestinal adverse events affected 47% to 84% of people on the drug versus 13% to 63% on placebo , while serious events stayed rare (Moiz and colleagues, systematic review, Annals of Internal Medicine , 2025)
Ranging from oxidative stress, and microglial activation to even apoptosis of neurons
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Semaglutide trials (STEP program) reported nausea in approximately 25-35% of participants at therapeutic doses
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