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On paper the two are complementary rather than redundant one stops a leak, the other adds water to the tank
By blocking NNMT, it shifts intracellular NAD+ and S-adenosylmethionine (SAM) levels, two cofactors tied to energy metabolism, redox balance, and gene regulation in laboratory models
The BUD is the date or time after which the preparation should not be used
However, it also have potential side effects which must be considered
This means AOD 9604 can be used for extended periods without diminishing returns from antibody-mediated inactivation
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