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Leveraging gene-environment interactions and endotypes for asthma gene discovery
Observational studies in humans report lower circulating spexin levels in obesity and metabolic syndrome, supporting its role as an endogenous metabolic regulator rather than a stress-induced peptide (Lv et al., 2019)
These often happen during dose escalation and usually improve over time and with adequate support from a healthcare provider
In the SURMOUNT-1 trial, tirzepatide 15 mg weekly produced mean weight loss of 22.5% at 72 weeks significantly exceeding semaglutide results
S., Bloom, S
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