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In POF, the ovaries lose their germinative and hormonal functions because of the exhaustion of the number of ovarian follicles before the typical age for physiological menopause which is around 50 years of age
AOD9604 and Safety Pharmacology Research A conventional Ames test showed no significant mutation rate increase for AOD9604 at up to 2,000 g/plate, with no clastogenic effects observed in CHO-cell chromosome aberration assays
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Both groups had a slower renal function decline after treatment than before treatment
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