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In the brain, semaglutide acts on appetite centers to: Reduce hunger Slow eating Increase feelings of fullness It also delays gastric emptying so food stays in the stomach longer, which helps reduce meal size

Dehydration hardens stool and makes constipation worse

Dr Kosiborod has served as a consultant or on an advisory board for 35Pharma, Alnylam, Amgen, Applied Therapeutics, AstraZeneca, Bayer, Boehringer Ingelheim, Cytokinetics, Dexcom, Eli Lilly, Esperion Therapeutics, Janssen, Lexicon Pharmaceuticals, Merck (Diabetes and Cardiovascular), Novo Nordisk, Pfizer, Pharmacosmos, Sanofi, scPharmaceuticals, Structure Therapeutics, Vifor Pharma, and Youngene Therapeutics

By targeting these pathways simultaneously, GLP-2 delivers comprehensive metabolic improvements that extend beyond glucose control

The surgery can provide up to 60%-70% excess weight loss that will be permanent, compared to around 20% body weight loss from using the drug that stops working once payments stop