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Therapeutic targeting of the mitochondrial one-carbon pathway: perspectives, pitfalls, and potential
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Thus, in perfect agreement with the recent ADA-EASD consensus report [6], we also encourage the adoption of GLP-1RA plus SGLT2i combination therapy in T2DM patients with established ASCVD (coronary artery disease, cerebrovascular disease, or peripheral arterial disease) or multiple risk factors for ASCVD (i.e., age 55 years, obesity, dyslipidemia, hypertension, current tobacco use, left ventricular hypertrophy, and/or proteinuria) whose HbA1c remains suboptimal despite initial treatment with only one of these agents
PallardFVMarkovicJGarcaJLViaJ
Therefore, the effect of l-Carnitine on autophagy induction in a given type of cell can differ depending on the circumstances, it can protect cells from damage either by increasing or suppressing autophagy induction in C2C12 cells
