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Studies using hippocampal tissue obtained from patients with temporal lobe epilepsy and a mouse model of pilocarpine-induced epilepsy have shown that decreased GLP-1R expression in hippocampal microglia correlates with increased cytokine release and astrocyte activation [73]
In terms of prognosis, the 5-year event-free survival (EFS) was 84.9% (SE 3.4%) for pegaspargase and 88.1% (SE 3.0%) for calaspargase pegol
Animal and Laboratory Research Preclinical research supports biological plausibility but cannot establish human treatment outcomes by itself
This dual pathway provides more robust signals to the brain regarding fullness and satisfaction
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