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In many cancer types, FAO is downregulated under hypoxia to reduce mitochondrial oxygen consumption and minimize ROS production, a strategy that aligns with the broader suppression of oxidative metabolism

In the SURPASS-2 study, the three doses of tirzepatide (5, 10, and 15 mg once weekly) were tested with the GLP-1RA semaglutide (1 mg once weekly) as a comparator in patients not optimally controlled on monotherapy with metformin (71)