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It is enveloped by an extracellular matrix composed of -1,3 glucan, -1,6 glucan, and -1,2-branched -1,6 mannan (Nobile and Johnson, 2015
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Studies in mice and humans show that innate and adaptive immune responses, involving macrophages, neutrophils, natural killer cells, B and T lymphocytes, should control the parasite through the production of ROS/RNS, proinflammatory T H 1 cytokines, trypanolytic antibodies, and cytotoxic T lymphocytes' activity
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