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Parkinsons disease-associated Dj-1 mutations increase abnormal phosphorylation of tau protein through Akt/Gsk-3 pathways

Emerging evidence demonstrates that miRNAs are critical regulators of lipid synthesis and FAO 81 resulting in defective cell metabolism and carcinogenesis 82 directly targeting key enzymes or transcription factors as oncogenes and tumor suppressors 81 as shown in Table 1

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LC/MS assay) - Lipids (LDL, HDL, Triglycerides) - Comprehensive Metabolic Panel (CMP) (Glucose, electrolytes, liver/kidney functions)

These mechanisms include the activation or repression of gene expression by TFs, the impact of DNA-embedded enhancers and silencers, the regulation and post-translational modification of transcriptional regulators, and epigenetic modifications such as DNA methylation and histone modifications