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Benefits (Research Focus) Studied as a high-affinity potentiator of hepatocyte growth factor (HGF) signaling (Kd 65 pM) Investigated for c-Met receptor activation and downstream signal transduction Explored for functional dendritic spine formation and synaptic connectivity Examined in rodent models of Alzheimers-like cognitive impairment Researched as a structurally optimized angiotensin IV / AT4 receptor analog What Researchers Look At HGF / c-Met receptor binding affinity and phosphorylation cascades Dendritic spine density and synaptic protein expression in hippocampal cultures Long-term potentiation (LTP) and electrophysiological endpoints in brain slice models Cognitive performance in aged and AD-model rodents (Morris water maze, object recognition) Comparative neurotrophic mimetic pharmacology versus BDNF and NGF Quick Specs Form: Gelatin capsule Strength: 5 mg / capsule Quantity: 30 capsules per bottle Excipient: Microcrystalline cellulose (MCC) pharmaceutical-grade filler Purity: 99% Storage: Store in a cool, dry, dark place Identity Basics Compound: Dihexa Synonyms: PNB-0408

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10.1007/s00401-015-1436-x 276 PrattA

& Ferencik, M

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