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For instance, in 3xTg-AD mice, sex-specific alterations in brain bioenergetics have been observed: females showed impaired complex I activity in synaptic cortical mitochondria, while non-synaptic mitochondria exhibited enhanced complex IImediated respiration (Stojakovic et al., 2021)

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doi:10.1016/j.jad.2025.119670 31

Common Praise Patients on long-term HRT frequently report consistent testosterone and estradiol levels across refills, suggesting batch-to-batch potency reliability