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Hagen TM, Wierzbicka GT, Sillau AH, Bowman BB, Jones DP

Neurosci Lett 2001;313(1-2):78-82

Similarly, a specific T2R38 agonist, phenylthiourea, induced GLP-1 secretion from HuTu-80 cells, an effect markedly inhibited by silencing of T2R38 with small interfering RNA (36), In contrast, 1,10-phenanthroline stimulates GLP-1 via T2R5 (39), and DB appears to induce GLP-1 secretion via a broad range of BTRs (including T2R4, T2R43, and T2R46 at least), in NCI-h716 cells (21)

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Till date, eight different isozymes, viz., GPx1-GPx8, have been identified in humans, of which GPx1, GPx2, GPx3, GPx4, and GPx6 are selenoenzymes containing Sec in their active site (Table 1) [1, 8, 9]