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Metabolic considerations : While adipose tissue has some metabolic activity, skeletal muscle is the primary contributor to resting metabolic rate and heat production
The Ozempic ladder reaches 2.0 mg weekly, but doubling from 1.0 to 2.0 mg added only about 0.23 percentage points of HbA1c reduction and 0.9 kg of weight loss. Beyond 1.0 mg, most of the added effect is on weight rather than glucose
The STEP trials (semaglutide) and SCALE trials (liraglutide) have provided compelling data on substantial and sustained weight loss
Roux-en-Y-Bariatric Surgery Reduces Markers of Metabolic Syndrome in Morbidly Obese Patients
In addition, acute renal infusion with GLP-1 can augment renal blood flow and promote natriuresis and dieresis [69]
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