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Muscle loss from rapid weight loss One of the most significant contributors to body aches on GLP-1 medications is muscle mass loss

References: Baggio LL, Drucker DJ (2007): Biology of incretins: GLP-1 and GIP

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When Your Doctor Might Consider Phentermine Instead of Semaglutide Phentermine remains a valid option for short-term weight loss in patients who cannot tolerate GLP-1 medications, have contraindications to semaglutide (such as personal or family history of medullary thyroid carcinoma), or require rapid appetite suppression for a defined period

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