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The gene, mapping on chromosome 6, has been identified in 2002 in two parallel studies that classified CT2 as the sixth member of the OCT subfamily (Gong et al., 2002)

PMID: 19393193

In preclinical models, GIP has been shown to decrease food intake and increase energy expenditure therefore resulting in weight reductions, and when combined with GLP-1 receptor agonism, may result in greater effects on markers of metabolic dysregulation such as body weight, glucose and lipids

10.1038/cdd.2009.107 Cell Death Differ

The GHR-R antagonist JMV 2959 neither induces malaise nor alters the malaise property of LiCl in the adult male rat