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Skin water content, transepidermal water loss (TEWL), skin elasticity, skin thickness, and the level of NMF constituents were determined in the SC at baseline and then at 12 weeks

Despite these shortcomings, this study was the first to demonstrate the beneficial effects of oral glutathione in skin lightening

Notice that GSH goes up for low estradiol values, reaches a peak and descends for high estradiol values Variation of GSH steady state depending on S In our model, we take the activation of GCL and GPX by estradiol to be 80%, which is a reasonable choice supported by the experimental and clinical data discussed above