Future research should focus on large-scale, well-controlled randomized trials with standardized dosing protocols, clearly defined deficiency thresholds, and long-term follow-up to strengthen the evidence base and guide clinical practice
Sikiric P, Boban Blagaic A, Strbe S, Beketic Oreskovic L, Oreskovic I, Sikiric S, et al
It is not approved, and is not intended, for diagnosis, treatment, cure, or prevention of any disease in humans or animals
This puts anyone following a strict vegan or vegetarian diet at a very high risk for deficiency
It is also almost entirely preclinical