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Others use NSAIDs for acute flares while relying on peptides for ongoing support

Injections bypass that step, so more B12 becomes available to tissues

This rapid clearance may help prevent the toxic accumulation of mediators in the bloodstream, significantly reducing the severity and duration of systemic MCAS flares, such as flushing, gastrointestinal distress, and neurological inflammation

The MHRA advises checking B12 levels in patients taking metformin who develop symptoms of deficiency or have risk factors, with periodic monitoring in at-risk patients

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