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The combination prevents both reuptake and breakdown of monoamines, creating serotonin syndrome risk
Individuals with MTHFR polymorphisms or baseline methylation impairments may want to monitor homocysteine levels if using 5-Amino-1MQ beyond 12 weeks
We selected these trials due to their similarities in assessing patients with both obesity and T2D, treatment duration, clinical development phase (phase 3), and use of semaglutide as an active treatment arm
Results supported advancement to Phase 3 and combination therapy development
Mowla SJ, Farhadi HF, Pareek S, Atwal JK, Morris SJ, Seidah NG, et al
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