Both require collagen synthesis, extracellular matrix formation, and tissue remodeling
Truly disease-modifying treatments would be expected to produce increasingly divergent outcomes between treated and untreated patients over years, and this has not been clearly demonstrated in clinical trials
The simplest of these compounds were identified as 1,4-benzenediol (hydroquinone), tert-butylhydroquinone, and 1,2-benzendiol (catechol), and more complex examples include the isothiocyanate sulforaphane from broccoli seed extract, curcumin from the turmeric plant and carotenoids such as zeaxanthin and lutein
Here's how it works: 1
Because the induction of these genes is only transient, the glutamate consumption is likely to be buffered by steady-state central carbon metabolism, under which glucose and glutamate fuel mitochondria to support cellular bioenergetic demands (Fig