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This fundamental characteristic makes a true vitamin B12 overdose exceptionally rare in clinical practice

Other types, like hydroxocobalamin, might be used for different reasons

Its enhanced stability and resistance to enzymatic degradation make it a preferred research tool for investigating GH-related physiology and GH-independent mechanisms 1

Published data suggests up to 2.6% incidence of B12 deficiency within a year of treatment, and this figure climbs in patients who have used these medications long term or combined them with very low calorie diets (3)