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Embedded hydroxy,unsaturated epoxyketone becomes electrophilic only inside the enzyme, acting as a solubilityswitching warhead
This is why patients seeking measurable results, brighter skin, faster recovery, support during high oxidative stress conditions, often choose IV protocols
When this DNA repair pathway is not functional, cells are more sensitive to compounds that can damage the DNA such as DNA interstrand-crosslinking (ICL) agents and simple aldehydes 11
10.1073/pnas.202422899 229 WilkinsonS
The situation is further compounded by the presence of posttranslational modifying factors, such as kinase activities and S -glutathionylation
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