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Additionally, further research is needed to explore the broader therapeutic potential of these agents in managing comorbidities such as cardiovascular disease, PCOS, CKD, MASH, and osteoarthritis

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It not only induces breakdown of the existing BBB, but also promotes the growth of structurally altered capillaries (abnormal expression of transporters and receptors) to meet the high metabolic demand of the tumor (Mo et al., 2021)

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10.3390/biomedicines9101300 22 GojkovicS.KrezicI.VrdoljakB.MalekinusicD.BarisicI.PetrovicA.et al (2020)

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