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Circulating TMAO enhances BBB integrity in both homeostasis and LPS-induced inflammation by increasing annexin A1 signaling in endothelial cells and protecting against inflammation-associated memory impairment in wild-type mice [233]
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Geraniol, a compound in the anthocyanin family, decreases DNA methylation in the NRF2 promoter region of mouse skin epidermal JB6 (JB6 P+) cells and enhances the expression of NRF2 downstream target genes
According to Hirst and Moutier (24), the transition to parenthood is a stressful event in life, and exposure to such events can trigger the first episodes of mania or potentially severe mixed states
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