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Extended-release metformin at 2,000 mg daily provides the maximum therapeutic effect

Because this effect is entirely glucose-dependent, insulin secretion decreases as plasma glucose approaches normal levels, providing a significant safety advantage over traditional secretagogues

Multiple pregnancies: Women carrying more than one baby have higher micronutrient needs than women carrying one baby

Mar 2024;75(2):122-133

Regular HbA1c testing (typically every three months until stable, then potentially every six months), self-monitoring of blood glucose as directed, and periodic weight checks allow you and your healthcare provider to assess treatment response