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Reports of GLP-1-associated gastroparesis have increased as prescribing has expanded

However, the physiological effects (such as changes in inflammation or tissue healing signals) may last longer than the measurable presence of the peptide

10.1074/jbc.273.49.32377 J

Although the direct cytotoxic effects of high cellular GSSG levels have been documented in a variety of cell types 33,34,35,36 , our cell culture studies with hepatocytes revealed that increased GSSG accumulation, despite being non-toxic per se, could sensitize hepatocytes to TNF-induced killing, suggesting that GSSG and TNF can synergistically induce hepatocyte death and that GSSG-triggered sensitization to TNF hepatotoxicity represents a clinically relevant process that may account for disease progression in NAFLD

However, it is important to understand that animal research does not automatically translate to long-term safety in humans