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If the patient cannot tolerate the 2.4mg dose, then discontinue semaglutide
GLP-1 agonists are being used in combination with basal insulin (Dungan & DeSantis, 2016), although this is not an FDA-approved indication (see rxlist.com) they should not be used as a substitute for basal insulin, as this has been found to result in a decline in glycemic control)(Dungan & DeSantis, 2016) Clinical trials indicate it can reduce HbA1c by ~0.8% Undergoes renal clearance, with dosage reduction needed if creatinine clearance falls to 25 mL/min, while European guidelines recommend a lower eGFR limit of 20 ml/min (Thomas et al, 2023)
Diverse roles of macrophages in atherosclerosis: From inflammatory biology to biomarker discovery
rather, these represent individual variations in treatment response that merit clinical attention and potential management adjustments
Conditional analysis did not identify independent associations within the locus for either trait (Extended Data Fig
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