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Several mechanistic pathways have been hypothesized to underpin these clinical observations, which involves the influence of GLP-1RA on inflammatory, oxidative stress, and angiogenesis pathways in the atherosclerotic process [69,70,71,72]

PMID: 26236730 Published Research Highlights Discovery 1973 Tripeptide Identified in Human Serum Pickart and Thaler first identified the GHK sequence in human plasma, discovering a tripeptide that prolonged survival of normal liver cells and stimulated growth in cell culture models

However, we would suggest that future clinical trials should aim to assess the cost-effectiveness of screening older people with obesity who are undergoing weight management interventions for evidence of sarcopenia, through clinical evaluation including hand grip tests, which are accurate biomarkers for overall strength and function, bone mineral density and consequent fracture risk, and cardiometabolic disease [123]

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