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Studies show GLP-1-only agonists (like semaglutide) produce 15-17% weight loss at maximum doses, making it the foundation of the triple-agonist effect

In some cases, patients may also experience belching, a bloated feeling, and passing gas

Most side effects are manageable and may decrease with time, while others may require more attention

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H 2 O 2 produced during the oxidative folding of endoplasmic reticulum proteins has been found to regulate the signal transduction process of nuclear factor E2-related factor 2 (Nrf2), which in turn regulates the expression of downstream glutathione peroxidase 8 (GPX8), which in turn can participate in ER calcium regulation through endoplasmic reticulum calcium ATPase (SERCA) (Figure 7)