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In rodent studies, semaglutide caused dose-dependent and treatment-duration-dependent thyroid C-cell tumors at clinically relevant exposures
Primary Handling Editors: Rosie Bunton-Stasyshyn & Mengtan Xing
10.1016/j.lfs.2004.04.038 30 ChauhanA.GuF.EssaM
In 2025, an independent group at Brunel University London reported dose-dependent telomere length extension in normal human cells, the first solid Western replication of that claim
Notably, in a recent chemical screen in the ferroptosis-sensitive HT-1080 N fibrosarcoma cells, seven out of eight PI3K/mTOR inhibitors suppressed the ferroptosis-inducing activity of erastin and sorafenib, but not the covalent GPX4 inhibitor, ML162 19
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