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In the Central Nervous System GH and IGF-1 both contribute to neural development, nerve myelination, amyloid clearance so important in the development of Alzheimers disease and anti-inflammatory mechanisms within the central nervous system

Holding GLP-1 RAs for five half-lives can lead to normalization of gastric emptying

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They are synthesized by gonads and adrenal glands or derive from the conversion of other sex steroids in some tissues, including liver and fat [20]