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Retatrutide produces exceptionally large improvements in weight, hepatic fat, and the biomarkers of insulin resistance in adults with obesity, type 2 diabetes, and MASLD

Broadfield LA, Duarte JAG, Schmieder R, Broekaert D, Veys K, Planque M, et al

Prospective cohort data identify avoiding grazing, stopping when full, and weekly selfweighing as key predictors of favorable outcomes [112]

Both drugs carry a boxed warning regarding the risk of thyroid C-cell tumors