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Gleeson M, Pyne DB
Lower testosterone levels can lead to an increase in stored fat, insulin resistance, and a higher risk of type 2 diabetes all of which can make weight loss more difficult
It suggests the drug reached the brain and affected disease-relevant pathways, but that timing, magnitude, delivery, or patient selection were insufficient to overcome established neurodegeneration when used as a stand-alone therapy
www.who.int/news-room/fact-sheets/detail/obesity-and-overweight Carnell, S., Gibson, C., Benson, L., Ochner, C
This long half-life is what makes once-weekly dosing possible
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