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Caspase-3 activation is an early event and initiates apoptotic damage in a human leukemia cell line

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In lipopolysaccharide primed macrophages, capsaicin induced TRPV1 activation and Ca 2+ influx promote polarization toward an M2 macrophage phenotype characterized by anti-inflammatory properties, thereby improving the adipose tissue inflammatory microenvironment and attenuating insulin resistance (63)

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