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Several pharmacovigilance analyses assessed a potential association between GLP-1 receptor agonists and suicidality, several of which found significantly increased reporting odds ratios for at least one safety signal.41424344 Although useful for signal generation, pharmacovigilance analyses are subject to incomplete reporting and confounding and have limited use in establishing causal associations

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However, many of these medications carry a boxed warning from the FDA regarding a potential risk of thyroid C-cell tumors, including medullary thyroid carcinoma (MTC)

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& Kanoski, S