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Intriguingly, although tirzepatide closely resembles native GIP in how it activates the GIPR, it differs markedly from GLP-1 in its activation of the GLP-1R, resulting in less agonist-induced receptor desensitization

10.1038/sj.ki.5002176 145 TianL

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Then, enzymes called peptidases which are designed to break protein bondsstart to dismantle the glutathione into its individual amino acids