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Food and Drug Administration (FDA)-approved GLP-1 semaglutide and tirzepatide products), as they have been removed from the FDAs shortage list

The current community consensus, reflected in clinic protocols and forum guidance alike, is to split doses where possible

Furthermore, since Mounjaro mimics GLP-1 hormone effects, it may influence bodily fluid balance and potentially impact tear production and evaporation

If a patient is already taking antihypertensive medications (ACE inhibitors, beta-blockers, diuretics), their physician may need to adjust doses downward as GLP-1 takes effect, preventing hypotension

The abdomen and thigh are the most commonly recommended because they offer the best combination of subcutaneous fat for absorption and ease of self-administration