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Serious reactions are rare but can include rash, wheezing, trouble breathing, or swelling of the face or throat

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Abbreviations 1 H NMR: Proton nuclear magnetic resonance 3-PBLG: 3-Armed poly(-benzyl-l-glutamic acid) 3-PLG: 3-Armed poly(l-glutamic acid) 3-PLG-A-GSH: 3-Armed poly(l-glutamic acid) coupled with alanine and glutathione 3-PLG-dopa: 3-Armed poly(l-glutamic acid) coupled with dopamine 3-PLG-dopa-A-GSH: 3-Armed poly(l-glutamic acid) coupled with dopamine and alanine and glutathione targeting ligands 3-PLG-ibu: 3-Armed poly(l-glutamic acid) coupled with ibuprofen 3-PLG-ibu-A-GSH: 3-Armed poly(l-glutamic acid) coupled with ibuprofen and alanine and glutathione targeting ligands A-GSH: Alanine and glutathione targeting ligands AD: Alzheimer's disease ASCT: Neutral amino acid transporter BBB: Bloodbrain barrier BLG NCA: L-glutamic acid -benzyl ester N -carboxyanhydride BSA: Bovine serum albumin cARLA: 8-(4-Chlorophenylthio)adenosine 3,5-cyclic monophosphate sodium salt + Ro-20-1724 + LiCl + A83-01 CD: -Cyclodextrin CK: Cytokines CNS: Central nervous system CytoD: Cytochalasin D D 2 O: Deuterium oxide DCM: Dichloromethane DIW: Deionized water DMEM: Dulbeccos modified Eagle medium DW: Distilled water EBA: Evans blue-albumin complex EDC/NHS: N -Ethyl- N -(3-(dimethylamino)propyl)carbodiimide/ N -hydroxysuccinimide EG 2 -diamine: 2,2-(Ethylenedioxy)bis(ethylamine) FBS: Fetal bovine serum GLUT-1: Glucose transporter type-1 hEC: Human stem cell-derived endothelial cells IL1-: Interleukin-1 LAT-1: L-type amino acid transporter-1 LRPs: Low density lipoprotein receptor-related proteins NA: Neuraminidase NSAIDs: Non-steroidal anti-inflammatory drugs P app : Apparent permeability coefficient PBS: Phosphate buffered saline PD: Parkinsons disease PDI: Polydispersity index PC: Pericytes PLGA: Poly(lactic- co -glycolic acid) R6G: N -(2-Aminoethyl) rhodamine 6G-amide bis(trifluoroacetate) SF: Sodium fluorescein SLC: Solute carrier SNAT: Small neutral amino acid transporters THF: Tetrahydrofuran TMA-DPH: 1-(4-Trimethylammoniumphenyl)-6-phenyl-1,3,5-hexatriene TMSI: Trimethylsilyl iodide TNF-: Tumor necrosis factor- References Abbott NJ, Patabendige AA, Dolman DE, Yusof SR, Begley DJ

Sp could restore the redox balance, mitochondrial function, and prevented oxidative damage, leading to recovery of dopaminergic neural networks and motion abilities in Drosophila genetic model of PD

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