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COPD and multimorbidity: recognising and addressing a syndemic occurrence
10.1111/epi.12923 19 GhoshC.HossainM.SolankiJ.DadasA.MarchiN.JanigroD
GLP-1 signaling may improve mitochondrial biogenesis via PGC-1a/nuclear respiratory factor-1/mitochondrial transcription factor A signaling regulated by adiponectin/ adenosine 5-monophosphate (AMP)-activated protein kinase (AMPK) 49 and elevates the expression of NAD-dependent protein deacetylase sirtuin 1 (SIRT1), which increases the expression of Parkin, leading to mitophagy activation
A thorough assessment should include review of other medications (antidepressants, antihypertensives, and hormonal contraceptives commonly affect sexual function), evaluation for mood disorders including depression and anxiety, assessment of relationship factors and psychosocial stressors, and consideration of underlying medical conditions such as thyroid dysfunction, diabetes complications, or cardiovascular disease
