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This work was supported by Laboratori Farmaceutici Krymi SpA (Rome, Italy)

The oxidative stress-induced niacin sink (OSINS) model for HIV pathogenesis

27 Also, fasting (by shunting acetaminophen metabolism away from glucuronidation or by depletion of intracellular GSH) and chronic ethanol use (via intracellular GSH depletion) can increase susceptibility to acetaminophen hepatotoxicity