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However, when very high oral doses are taken, approximately 1% can be absorbed through passive diffusion, independent of intrinsic factor, which explains how mega-doses can still raise serum levels

No muscle loss was observed, indicating that weight reduction came specifically from fat tissue rather than lean body mass

The muscle is obviously deeper than your subcutaneous tissue (you can see the image above for reference)

(Frontiers in Nutrition, 2026 review)

Most patients begin to notice changes in body composition, energy, or recovery within 46 weeks, though optimal results are typically seen after 812 weeks of consistent use, alongside healthy lifestyle habits