For some, they can be life-changing
Medication Mechanism of Action Average Weight Loss Retatrutide Triple agonist (GLP-1, GIP, Glucagon) Up to 24% average weight loss over 48 weeks Semaglutide GLP-1 receptor agonist Up to 17% over 68 weeks Tirzepatide Dual agonist (GLP-1, GIP) Up to 25% over 52 weeks Retatrutide is used to help with weight loss
Anyone with a personal or family history of certain thyroid cancers, pancreatitis, or serious gastrointestinal disease sits outside the comfortable-experimentation zone these compounds occupy, since those conditions appeared in trial exclusion criteria for good reason
Your provider will help determine what makes the most sense based on your progress and overall health
3.3 The role of SCFAs in MetS The core of MetS development is insulin resistance, which could be affected by gut microbiota-derived metabolites