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It also helps prevent micro- and macrovascular complications caused by poor circulation

The endogenous intestinal GLP-1 sequence corresponded to a truncated form of GLP-1, formed by a monobasic cleavage between residues 77 and 78 in proglucagon, resulting in an amidated peptide with the full sequence of PG 78106 amide [29]

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Ser133-phosphorylated CREB together with CRTC upregulates CREB target genes such as the gluconeogenesis-related genes PGC1, nuclear receptor subfamily 4 group A member 1 (NR4A1) and TFEB which regulates gene expressions of autophagy proteins (Ueno and Komatsu, 2017)