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2 GLP-1 receptors are expressed in brain regions involved in satiation, satiety, and reward, including the hypothalamus, brainstem, and mesolimbic pathways
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One of the possible reasons for this is that metformin inhibits sodium-glucose cotransporter1 (SGLT1) on small intestinal epithelial cells, decreasing the intra- and extracellular Na + concentration gradient, thereby inhibiting intestinal glucose absorption and increasing glucose utilization (Lenzen et al., 1996
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