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1 Introduction 1.1 Atherosclerosis and coronary artery disease Coronary artery disease (CAD) is a cardiovascular condition occuring due to atherosclerotic plaque accumulation in the epicardial arteries, whether obstructive or non-obstructive ( Inflammation plays a key role in the formation of atherosclerotic plaquesthe primary pathological mechanism underlying CAD ( (IFN- ) and tumour necrosis factor (TNF)- , produced by immune cells, endothelial cells, platelets and fibroblasts are associated with atherosclerosis onset and progression

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According to a review encompassing several clinical trials involving topical GHK-Cu, the peptide can provide several benefits for the skin, including [4]: Tightening loose skin Reversing thinning of aged skin Improving skin firmness, elasticity, and clarity Reducing fine lines and depth of wrinkles, and improving the structure of aged skin Smoothing rough skin and improve overall skin appearance Protecting against UV and photoaging Reducing photodamage, mottled hyperpigmentation, skin spots, and lesions One randomized controlled trial reported that compared to a control serum, GHK-Cu applied topically twice daily in the course of 8 weeks reduced wrinkle volume by 55.8% and wrinkle depth by 32.8% in 40 female volunteers aged 40 to 65 years [17]

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