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In a study, it was highlighted that melatonin supplementation can prolong life and improve health span in rodents by lowering age-related oxidative and inflammatory markers (Reiter et al

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Therefore, iron overload in the peritoneal fluid may promote M2 macrophage polarization, inhibit the M1 macrophage phenotype and induce a subset of macrophage ferroptosis

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Nature 387 , 569572, (1997)

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