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however, the direct causal relationship requires further validation

Several findings have shown that metformin could suppress aromatase activity by inhibiting prostaglandin E2 (PGE2)-induced CYP19A1 and StAR expression in endometriotic stromal cells

Absorption rate: Though slower than IV and IM, absorption rate still performs well over time

However, inhibition of A accumulation by inhibiting APP--secretase and BACE1 was found to reduce the recovery after SCI indicating that A may also have neuroprotective role after SCI (Ahlgren et al., 1998

Evidence Gaps and Expectations: Crucially, patients must understand the experimental nature