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Notably, the WT strain exhibited significant enrichment of DEGs in several basal metabolic categories, including carbohydrate metabolism, as well as post-translational modifications (light blue bars) that contrast with the gsh strain that showed significant enrichment in the category related to energy production and conversion (burgundy bars)

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This intentional formulation directly addresses the critical need for muscle preservation for individuals on GLP-1 therapies

Pterostilbene (PTS) decreases the expression of HDAC and DNMT, leading to the demethylation of the NRF2 promoter and subsequent reactivation of NRF2