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Its historical connection with a pineal extract does not establish that the externally supplied peptide is a normal circulating human pineal hormone

Two primary reasons: First, immunogenicity

(2024) explored advanced delivery by evaluating GHK peptide-heparin interactions in multifunctional liposomal formulations, representing the frontier of GHK delivery technology where the peptide is packaged in lipid nanoparticles designed for controlled release and enhanced tissue penetration

Furthermore, to further ensure sterility, the vials of this Pfizer bacteriostatic water for injection, USP are constructed using a plastic-based flip-flop self-healing lid that closes as soon as the needle is retracted after taking a dose

Rare side effects include localized injection-site inflammation or mild itching